Effects of Oxidized Phospholipids and Heavy Water on the Structure of Phospholipid Bilayer Membranes
نویسنده
چکیده
The structural and dynamic organization and basic physicochemical features of 1,2dimyristoyl-sn-glycero-3-phosphocholine (DMPC) lipid bilayers were characterized upon the presence of two OxPLs, 1-palmitoyl-2-(9’-oxo-nonanoyl)-sn-glycero-3-phosphocholine (PoxnoPC) and 1-palmitoyl-2-glutaryyl-sn-glycero-3-phosphocholine (PGPC). The hydration behaviour of these systems was also studied by using the isotope effect of heavy water. The characterization of these systems was therefore performed by a combined biophysical approach of Differential Scanning Calorimetry (DSC) and Solid State 31 P, 2 H Nuclear Magnetic Resonance (NMR) to unravel in atomic detail the complex interactions between different types of lipids and the impact of water on these lipid bilayers.
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تاریخ انتشار 2011